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KMID : 0861020070220040137
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Korea Journal of Herbology
2007 Volume.22 No. 4 p.137 ~ p.143
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Inhibitory effect of the extract of Catalpa ovata G. Don. on endothelial adhesion molecule expression
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Choi Byung-Min
Chong Myong-Soo
Song Ho-Joon
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Abstract
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Objectives : Catalpa ovata G. Don (Bignoniaceae) has been shown to possess a variety of pharmacological activities. However, the effect of Catalpa ovata G. Don on endothelial adhesion molecule expression has not been reported.
Methods : To examine the effect of Catalpa ovata G. Don on the expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-{alpha} (TNF-{alpha}), we used various methods such as Western blot analysis, reverse tranascription-polymerase chain reaction (RT-PCR), and luciferase activity assay.
Results : 1. The extract of Catalpa ovata G. Don inhibited the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVECs stimulated with TNF-{alpha}. 2. The extract of Catalpa ovata G. Don reduced TNF-{alpha}-induced adhesion of leukocytes to HUVECs. 3. In addition, The extract of Catalpa ovata G. Don inhibited the promoter activities of ICAM-1 and VCAM-1.
Conclusions : These results that Catalpa ovata G. Don may be beneficial in the treatment of inflammatory such as atherosclerosis.
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KEYWORD
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Catalpa ovata G. Don, intracellular adhesion molecule-1, vascular cell adhesion molecule-1, human umbilical vein endothelial cells
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